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MVD of tumors by immunohistochemical staining of CD31. (A) In SKOV3ip1 tumors, rhLK8 significantly reduced the number of CD31-positive cells, and this effect was enhanced by combination treatment with rhLK8 and paclitaxel. (B) In HeyA8 tumors, treatment with paclitaxel alone significantly decreased MVD as determined by the number of CD31-positive cells, and this effect was intensified by rhLK8 treatment and most significantly by the combination of paclitaxel and rhLK8.
