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. 2014 May 13;7(3):384–392. doi: 10.1016/j.tranon.2014.04.009

Figure 1.

Figure 1

Rad6 and high molecular weight β-catenin forms are upregulated in melanoma lines. (A) Western blot analysis of Rad6 and β-catenin. High molecular weight species of β-catenin are indicated by a bracket. (B) transcriptional activity of β-catenin. Luciferase activity from TOP/Flash and FOP/Flash vectors were normalized against Renilla luciferase. Columns, mean of four independent experiments; bars, S.E. (P < .0001). (C) migration/invasion of the indicated cell models measured by Boyden chamber assay. Metastatic MDA-MB-231 breast cancer cells were included as a positive control. Results are expressed as mean ± S.E (P < .001) of replicate assays conducted in sextuplets.