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. 2014 Jun 17;7(3):331–340. doi: 10.1016/j.tranon.2014.04.011

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© 2014 Neoplasia Press, Inc. Published by Elsevier Inc. This is an open access article.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Calcium mobilization and induction of EMV biogenesis in 143B OS cells in the presence of forskolin and ionomycin. A1 and A2, show morphologic changes within ionomycin-sensitized 143B cells leading to the accumulation of intracellular, vesicles, whereas B1 and B2, show intracellular vesiculation in forskolin-pretreated and ionomycin-sensitized 143B cells as observed by confocal microscopy. C1 and D1, show kinetic changes in the Fura-2 ratio in ionomycin (C1) and in forskolin-pretreated, ionomycin-sensitized (D1) 143B cells. C2 and D2, compare Fura 350/375 between resting versus ionomycin (alone)–treated 143B osteosarcoma cells (C2) and resting versus forskolin-pretreated and ionomycin-sensitized (forskolin + ionomycin combination) 143B osteosarcoma cells (D2).