Figure 1.

Patient disposition. Not randomised=patients who did not meet inclusion criteria. SAR, sarilumab; q2w, every 2 weeks; qw, every week; MTX, methotrexate; all patients were required to receive and tolerate a minimum of 12 weeks of MTX treatment prior to the randomisation visit with a stable dose for 6 weeks prior to screening. All randomised patients received assigned treatment except one patient randomised to the placebo group who received in error a single 150 mg q2w dose (between days 57 and 78), and one patient randomised to the SAR 200 mg q2w group who did not receive study treatment.