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. 2014 Apr 25;99(9):850–856. doi: 10.1136/archdischild-2013-304831

Figure 2.

Figure 2

Transmission EM of a respiratory cilia from (A) a healthy individual. Representative nasal epithelium cilia from patients with primary ciliary dyskinesia (PCD) caused by (B) outer and inner dynein arm defects (C) transposition defect: some cilia demonstrate absence of a central microtubule pair (‘9+0’); in other cilia a peripheral microtubule doublet has crossed to take the central position providing an apparent ‘8+2’ structure (D) microtubular disorganisation. EM images obtained using FEI Tecnai 12 transmission electron microscope (FEI UK Limited, Cambridge, UK) at 80 kV). EM images provided by P Goggin (Primary Ciliary Dyskinesia Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK).