Table 5.

Summary of biomarker guided therapy studies.

	Goal natriuretic peptide concentration?	Successful natriuretic peptide reduction?	More aggressive care in natriuretic peptide arm?	Result
STARBRITE [50]	High	No	Yes	Neutral
PRIMA [42]	High	No	No	Neutral
SIGNAL-HF [51]	High	No	No	Neutral
UPSTEP [52]	High	Not reported	No	Neutral
TIME-CHF [53]	Low	No	Yes	Positive trend
BATTLESCARRED [54]	Low	No	Yes	Positive trend
Troughton, et al [55]	Low	Yes	Yes	Positive
STARS-BNP [56]	Low	Not reported	Yes	Positive
Berger, et al [45]	Low	Yes	Yes	Positive
PROTECT [46]	Low	Yes	Yes	Positive