Table 2.

Performance of Clinical & HD-CTM Models

		NSCLC vs. Benign			Stage I vs. Benign
		Training n = 88	Test n = 41	All n = 129	Training n = 71	Test n = 34	All n=105
Clinical Variables Only*	AUC	0.78 (0.68–0.89)	0.75 (0.53–0.97)	0.77 (0.68–0.87)	0.80 (0.68–0.91)	0.76 (0.54–0.97)	0.79 (0.68–0.87)
	Sens	0.65	0.91	0.71	0.83	0.85	0.68
	Spec	0.88	0.63	0.80	0.71	0.63	0.84
Clinical & HD-CTM†	AUC	0.88 (0.81–0.96)	0.88 (0.66–0.99)	0.88 (0.82–0.94)	0.88 (0.79–0.97)	0.88 (0.75–1.00)	0.87 (0.82–0.94)
	Sens	0.79	0.72	0.82	0.82	0.78	0.83
	Spec	0.88	1.00	0.84	0.88	1.00	0.84

AUC = Area under curve (C-statistic) with 95% confidence interval. Sens = Sensitivity; Spec = Specificity.

^*See Table 1 for variables and levels included in the clinical model.

^†See Supplemental Table 2 for significant variables in each model. Models that significantly add value to the clinical model are in bold.