Table 2.
Summary of pathologic tumor stage changes from initial cT2N0, among patients with pathologic staging data available in NCDB
| Pathologic staging | Surgery first (n = 786) | Induction therapy (n = 477) | P-value |
|---|---|---|---|
| Accurate staging (pT2N0) | 210 (26.7%) | 116 (24.3%) | 0.34 |
| Upstaged (T or N) | 327 (41.6%) | 163 (34.2%) | 0.01 |
| Downstaged (T or N) | 249 (31.7%) | 198 (41.6%) | <0.001 |
| pT-stage | <0.001 | ||
| T0/IS | 6 (0.7%) | 110 (22.5%) | |
| T1 | 243 (30.1%) | 88 (18.0%) | |
| T2 | 334 (41.4%) | 187 (38.2%) | |
| T3 | 210 (26.1%) | 100 (20.4%) | |
| T4 | 13 (1.6%) | 4 (0.8%) | |
| pN-stage | 0.013 | ||
| Node negative | 549 (69.8%) | 381 (76.4%) | |
| Node positive | 237 (30.2%) | 118 (23.6%) | |
| Pathologic stage | <0.001 | ||
| pStage 0 | 1 (0.1%) | 23 (5.9%) | |
| pStage I | 220 (28.4%) | 95 (24.4%) | |
| pStage II | 409 (52.8%) | 209 (53.6%) | |
| pStage III | 128 (16.5%) | 58 (14.9%) | |
| pStage IV | 16 (2.1%) | 5 (1.3%) |