Table 2.
Adverse Events
| Adverse Event (Max Grade per Event) |
No. of Patients (Total=62) |
% |
|---|---|---|
| Patients with at least one of the following: | ||
| Grade 3/4/5 AE | 54 | 87.1 |
| Grade 4/5 AE | 21 | 33.9 |
| Grade 3/4 hematologic AE | 33 | 53.2 |
| Grade 4 hematologic AE | 13 | 21.0 |
| Grade 3/4/5 nonhematologic AE | 45 | 72.6 |
| Grade 4/5 nonhematologic AE | 10 | 16.1 |
| All Grade 4 hematologic AEs | ||
| Anemia | 1 | 1.6 |
| Lymphocytopenia | 1 | 1.6 |
| Neutropenia | 10 | 16.1 |
| Thrombocytopenia | 4 | 6.5 |
| Leukopenia | 1 | 1.6 |
| All Grade 4 nonhematologic AEs | ||
| Abdominal pain | 1 | 1.6 |
| Dyspnea | 1 | 1.6 |
| Fracture | 1 | 1.6 |
| Hypertension | 1 | 1.6 |
| Myocardial ischemia | 1 | 1.6 |
| Thrombosis | 1 | 1.6 |
| Ventricular tachycardia | 1 | 1.6 |
| Lower gastrointestinal hemorrhage | 1 | 1.6 |
| Sepsis | 1 | 1.6 |
| All Grade 5 nonhematologic AEs | ||
| Disease progression | 2 | 3.2 |
| Grade 3 or higher AEs occurring in ≥10% of Patients | ||
| Fatigue | 16 | 25.8 |
| Hypertension | 7 | 11.3 |
| Neutropenia | 18 | 29.0 |
| Thrombocytopenia | 11 | 17.7 |
| Grade 3 or higher Anemia/Hemorrhage | ||
| Anemia | 3 | 4.8 |
| Pulmonary hemorrhage | 1 | 1.6 |
| Lower gastrointestinal hemorrhage | 1 | 1.6 |
| Jejunal hemorrhage | 1 | 1.6 |