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Reduction of E6–E6AP complex formation by small molecule inhibitors. (a) ELISA-based assay IC50 curves for the association of E6 with E6AP in the presence of compound. Calculated IC50 values indicating the concentration of compound needed to reduce binding by 50% are reported. (b) Pull-down-based assay Western blot results for the same compound in an orthogonal solution assay. The degree of GST-E6 association with MBP-E6AP at each compound concentration was assessed by Western blot.
