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. 2014 Aug 12;5(4):e01438-14. doi: 10.1128/mBio.01438-14

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Copyright © 2014 Lukovac et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 3 — A. muciniphila regulates the expression of many host transcription factors and genes involved in cellular metabolic function. (A) Network representation of transcription factors affected by A. muciniphila, F. prausnitzii, and SCFAs. (B) Transcription factors affected in organoids after exposure to both A. muciniphila and its metabolite propionate. (C) IPA network demonstrating the effect of A. muciniphila on expression of genes involved in lipid metabolism. Nodes in green and red correspond to down- and upregulated genes, respectively. Noncolored nodes are proposed by IPA and suggest potential targets functionally coordinated with the differential genes.