Table 2.
Temporal changes in plasma levels of microRNA-483-3p, microRNA-1202 and plasma concentration of N-terminal pro brain natriuretic peptide after implantation of a left ventricular assist device
| Duration of LVAD support (months) | MicroRNAs | NT-proBNP | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | miR-483-3p | miR-1202 | |||||||||
| Exp., AU | FC from 0 months | P-valuea | Exp., A.U. | FC from 0 months | P-valuea | n | Concentration, ng/mL | RC from 0 months | P-valuea | ||
| 0 | 14 | 0.884 (0.857–0.957) | – | – | 1.308 (1.296–1.313) | – | – | 17 | 4724 (1526–20 890) | – | – |
| 3 | 9 | 0.915 (0.906–0.941) | 2.17 (1.43–2.62) | 0.011 | 1.308 (1.306–1.319) | 1.04 (0.85–1.57) | 0.515 | 13 | 924 (653–2792) | 0.23 (0.07–0.62) | 0.006 |
| 6 | 8 | 0.907 (0.891–0.923) | 2.27 (1.12–2.42) | 0.036 | 1.307 (1.304–1.326) | 0.94 (0.79–1.51) | 1.000 | 11 | 674 (524–1421) | 0.30 (0.08–0.43) | 0.004 |
| 9 | 7 | 0.922 (0.881–0.942) | 1.87 (1.64–4.36) | 0.028 | 1.314 (1.304–1.323) | 1.07 (0.71–1.71) | 0.612 | 9 | 873 (420–1300) | 0.14 (0.05–0.42) | 0.008 |
| 12 | 6 | 0.897 (0.851–1.011) | 2.82 (0.70–10.62) | 0.249 | 1.313 (1.290–1.320) | 1.14 (0.54–1.50) | 0.917 | 7 | 1190 (534–1367) | 0.26 (0.10–0.64) | 0.028 |
LVAD, left ventricular assist device; Exp, plasma expression in arbitrary units (AU); FC, fold change in miR expression from 0 months; miR, microRNA; RC, relative change in NT-proBNP as a proportion of NT-proBNP concentration at 0 months.
a
P-value for comparison vs. 0 months.