Table 1.
IC50 of hamigerone and radicinol in different cell lines.
| Cell line | IC50 in µM (±SD) | |||
|---|---|---|---|---|
| Hamigerone | Radicinol | Gemcitabine | Flavopiridol | |
| Panc-1 (pancreatic) | 1.9 ± 0.92 | 10.50 ± 1.4 | 0.38 ± 0.04 | 0.62 ± 0.05 |
| ACHN (renal) | 4.3 ± 0.78 | 14.28 ± 1.8 | 0.78 ± 0.07 | 0.91 ± 0.11 |
| Calu1 (lung) | 2.91 ± 1.1 | 12.60 ± 0.87 | 0.98 ± 0.11 | 0.79 ± 0.19 |
| H460 (non-small cell lung) | 2.42 ± 0.63 | 21.6 ± 3.2 | 1.23 ± 0.23 | 0.82 ± 0.09 |
| HCT116 (colon) | 2.91 ± 0.87 | 25 ± 2.9 | 1.15 ± 0.21 | 0.73 ± 0.08 |
| MCF10A (normal breast epithelium) | >30 | >30 | >10 | >10 |
IC50 values of hamigerone and radicinol in different cancer cells at 48 h. The cells were exposed to different concentrations at end of 48 h; cytotoxicity was measured using live cell dehydrogenase assay.