Table 2. Mean (SD) Attention-Deficit/Hyperactivity Disorder-Symptom Checklist (ADHD-SC4) Item Severity Scores for Parent Training, Stimulant, and Placebo (Basic) Versus Parent Training, Stimulant, and Risperidone (Augmented).
Symptoms | Baseline | Week 3 | Week 9 | p=a | p=b | Estimate (CI)b | ESc | |||
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
n | M (SD) | n | M (SD) | n | M (SD) | |||||
PARENT RATINGS | ||||||||||
ADHD | .051 | .129 | 0.15 (-0.04, 0.34) | .13 | ||||||
Basic | 84 | 2.4 (0.5) | 82 | 1.3 (0.8) | 71 | 1.0 (0.7) | ||||
Augmented | 84 | 2.3 (0.6) | 75 | 1.3 (0.7) | 66 | 0.8 (0.5) | ||||
ODD | .002 | .014 | 0.27 (0.06, 0.49) | .27 | ||||||
Basic | 84 | 2.4 (0.5) | 82 | 1.4 (0.9) | 71 | 1.1 (0.8) | ||||
Augmented | 84 | 2.3 (0.6) | 75 | 1.5 (0.8) | 66 | 0.8 (0.6) | ||||
CDd | NA | .145* | 0.06 (-0.02, 0.13) | .09 | ||||||
Basic | 84 | 0.6 (0.4) | NA | NA | 77 | 0.2 (0.2) | ||||
Augmented | 84 | 0.5 (0.4) | 73 | 0.1 (0.2) | ||||||
Peer Conflict Scale | .175 | .022* | 0.14 (0.02, 0.26) | .32 | ||||||
Basic | 84 | 1.5 (0.9) | 82 | 0.8 (0.8) | 71 | 0.6 (0.7) | ||||
Augmented | 83 | 1.5 (0.9) | 75 | 0.8 (0.8) | 66 | 0.3 (0.4) | ||||
TEACHER RATINGS | ||||||||||
ADHD | NA | .021 | 0.35 (0.05, 0.65) | .61 | ||||||
Basic | 46 | 1.6 (0.6) | 39 | 0.8 (0.7) | 48 | 0.8 (0.6) | ||||
Augmented | 40 | 1.8 (0.8) | 34 | 0.9 (0.7) | 38 | 0.6 (0.5) | ||||
ODD | NA | .120* | 0.17 (-0.04, 0.38) | .34 | ||||||
Basic | 46 | 1.2 (1.0) | 38 | 0.4 (0.6) | 48 | 0.4 (0.6) | ||||
Augmented | 40 | 1.5 (1.1) | 34 | 0.6 (0.8) | 38 | 0.4 (0.6) | ||||
CDd | NA | .087* | 0.14 (-0.02, 0.31) | .14 | ||||||
Basic | 45 | 0.4 (0.4) | NA | NA | 39 | 0.1 (0.2) | ||||
Augmented | 37 | 0.6 (0.6) | 30 | 0.1 (0.3) | ||||||
Peer Conflict Scale | NA | .163* | 0.15 (-0.10, 0.40) | .29 | ||||||
Basic | 46 | 0.7 (0.8) | 38 | 0.2 (0.5) | 48 | 0.2 (0.3) | ||||
Augmented | 40 | 0.9 (0.9) | 34 | 0.3 (0.6) | 38 | 0.2 (0.4) |
NOTE: CD = conduct disorder; ES=effect size (Cohen's d); ODD=oppositional defiant disorder, NA=not applicable.
P values for treatment multiplied by visit interaction.
P values and estimates (CI) represent results of mixed model for comparison of therapies at Week 9 (parents' ratings) or change from baseline to week 9 (teachers' ratings).
Effects size for baseline to Week 9 change.
From Child and Adolescent Symptom Inventory-4R.
p values, estimate (CI), and effect sizes represent results from square root transformation on specified CASI measures.