Figure 6.

Effect of noradrenaline reuptake inhibitors on anxiety- and depression-like behaviors induced by 6-OHDA. Sham, and 6-OHDA-lesioned mice treated for 4 days with saline, or reboxetine (20 mg/kg). An additional group of mice (red) was pretreated with desipramine (25 mg/kg) prior to lesion with 6-OHDA. Bar graphs show the immobility time (s) during the forced swim test (A; test duration, 10 min) and the time spent in the open arms (% of the test duration) during the elevated plus maze test (B; test duration 5 min). Data are expressed as mean ± s.e.m. (n = 7 − 21). ^**p < 0.01, ^***p < 0.0001, vs. sham mice, ^##p < 0.01, ^###p < 0.0001 vs. 6-OHDA-lesioned mice treated with saline, One-Way ANOVA, followed by Fisher post-hoc.