Figure 1. Complex IV activity is specifically affected in Surf1−/− heart and skeletal muscle.
A. Enzymatic activity of complexes I, II, III, and IV in isolated heart mitochondria from wild-type (white bars) and Surf1−/− (gray bars) mice. Values are normalized to wild-type control for each assay. B. Enzymatic activity of complexes I, II, III, and IV in isolated skeletal muscle (SkM) mitochondria from wild-type (white bars) and Surf1−/− (gray bars) mice. N=5 per experimental group, data are means ± SEM and significance determined by 2-tailed t-test, *p<0.05.