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. 2014 Aug 19;8:1125–1134. doi: 10.2147/DDDT.S64261

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© 2014 Devarakonda et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Study design.

Notes: Treatments consisted of two tablets of ER OC/APAP (15 mg OC/650 mg APAP) under: A) high-fat meal fed condition; B) low-fat meal fed condition; and C) fasted condition. ^aDuration of approximately 60 hours each, including an initial overnight (10-hour) fast, predose assessments and blood draws, and postdose pharmacokinetic sampling for 48 hours; ^b≥7 days; ^cparticipants were released from the study following their 48-hour blood draw and completion of the 48-hour postdose safety assessments; ^dongoing adverse events were followed via telephone for 7 days (with a visit window of plus 2 days) after period 3 study exit or early termination.

Abbreviations: APAP, acetaminophen; ER, extended release; OC, oxycodone.