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. 2014 Aug 19;8:1107–1123. doi: 10.2147/DDDT.S55621

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© 2014 Chimote et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Gross morphological changes in the zebrafish larvae following anti-angiogenic compound exposure at 96 hours.

Notes: Each compound is evaluated at five different concentrations, with 36 embryos/concentration and compound exposure for 96 hours. (A) Control larvae: normal phenotype. (B) VEGFR inhibitors: SU5416 treatment: jaw deformity (arrowhead), pericardial edema (arrows), and un-inflated swim bladder; vatalanib treatment: jaw deformity (arrowhead) and pericardial edema (arrows), slowed circulation; axitinib treatment: pericardial edema. (C) Multikinase inhibitors: sorafenib, regorafenib treatment: pericardial edema (arrows); suramin treatment: bent notochord, pericardial edema (arrows). (D) Inhibitors of endothelial cell proliferation: TNP-470 treatment: pericardial edema (arrows); thalidomide treatment: absence of fin development at 400 μM.

Abbreviation: VEGFR, vascular endothelial growth factor receptor.