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. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: Int J Cancer. 2006 Mar 1;118(5):1154–1158. doi: 10.1002/ijc.21446

Figure 1.

Figure 1

RT-PCR amplifications of the WWOX cDNA of OSCC. (a) Electrophoresis in polyacrylamide gel 6.5% was used to detect wild-type transcript (1284 bp) and alterations in the WWOX mRNA transcripts. Absence of transcript was seen in 2 tumors (#CA3 and #CA18) as well as 3 different types of aberrant transcripts: X (#CA2), Y (#CA12) and Z (#CA2, #CA5, #CA12, #CA21 and #CA24). (b–d), representative sequences from OSCC showing loss of exons (* represents a partial loss of the exon). (b), #CA5; (c), #CA12; (d) #CA2. (d) frameshift alteration in the open reading frame. (e) somatic mutation (C→T) of tumor #CA12, causing a S329F alteration.