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. 2014 Aug 27;8:252. doi: 10.3389/fncel.2014.00252

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Copyright © 2014 Courtney, Li and Lai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The nNOS:PSD95 interaction. Projection of crystal structure 1QAV.pdb (Hillier et al., 1999) of the nNOS extended PDZ domain (left) docking with a classI PDZ domain (right, from syntrophin in this case). The parallel β-sheet 2/α-helix 2 regions that form the ligand binding pockets of the PDZ domains are labelled in each domain. The β finger of the nNOS extended PDZ that docks in the classI PDZ domain is shown in brown, revealing that the PDZ ligand binding pocket of nNOS (arrow, left) remains unoccupied. This projection was generated with Accelrys Discovery Studio.