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. 2013 Apr 5;8(10):900–908. doi: 10.3969/j.issn.1673-5374.2013.10.004

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of minocycline (MT) on cerebral infarction volume in the hippocampal CA1 region of rats after cerebral ischemia-reperfusion (I/R) (tetrazolium chloride staining).

(A) Tetrazolium chloride staining results showed uniform staining in the sham-operation (Sham) group, and a pale infracted locus in the I/R group and MT group. Compared with the I/R group, infarction volume was significantly reduced in the MT group.

(B) Infarction volume analysis of cerebral I/R. Data are expressed as mean ± SD (n = 6), and were analyzed using one-way analysis of variance. ^aP < 0.05, vs. sham group; ^bP < 0.05, vs. I/R group. 1 and 3 days mean the time of MT treatment.