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. 2013 Apr 5;8(10):900–908. doi: 10.3969/j.issn.1673-5374.2013.10.004

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of minocycline on neuronal apoptosis in the hippocampal CA1 region of rats after cerebral ischemia-reperfusion (I/R) (TUNEL staining, × 200).

(A) Cell apoptosis in the hippocampal CA1 region. Cell apoptosis was not observed in the sham-operation group; the number of apoptotic cells in the minocycline group was significantly less than in the I/R group. Arrows point to apoptotic cells.

(B) Apoptotic index analysis in cerebral I/R rats after treatment for 1 and 3 days. The apoptotic index was calculated using the equation: TUNEL-positive cells/total number of cells × 100%. Data are expressed as mean ± SD (n = 6), and were analyzed using one-way analysis of variance. ^aP < 0.05, vs. sham-operation group; ^bP < 0.05, vs. I/R group.

TUNEL: Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling.