Figure 4.

Effect of penehyclidine hydrochloride (PHC) on the expression of NR1 mRNA in hippocampal cells.

1: High-dose PHC group (1.6 μM); 2: middle-dose PHC group (0.4 μM); 3: low-dose PHC group (0.1 μM).

Compared with the O/R model group, except at the 1-hour reperfusion injury period, PHC at each concentration in the study could reduce NR1 subunit expression to varying degrees at different reperfusion injury time. Data are expressed as mean ± SD (n = 3; one-way analysis of variance followed by least significant difference test). ^aP < 0.05, vs. O/R-6 h group; ^bP < 0.05, vs. O/R-12 h group; ^cP < 0.05, vs. O/R-24 h group.

O/R: Oxygen-glucose deprivation and reperfusion; h: hour; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.