Figure 4.

Connexin 43 expression in brain tissues of rats after traumatic brain injury (immunohistochemical staining, ×400).

The brown granules (arrows) indicate connexin 43 positive expression.

(A) Sham-surgery group: Connexin 43 was scarcely expressed. (B) 2 hour trauma group: Connexin 43 was lowly expressed and the expression level was not increased. (C) 6 hour trauma group: Connexin 43 expression was significantly increased.

(D) 24 hour trauma group: Connexin 43 expression reached the peak. (E) 3 day trauma group: Connexin 43 was highly expressed. (F) 5 day trauma group: Connexin 43 expression was decreased, which was still higher than that in sham-surgery group.