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. 2013 Dec 25;8(36):3423–3433. doi: 10.3969/j.issn.1673-5374.2013.36.008

Figure 3.

Figure 3

Reactive oxygen species (ROS) and malondialdehyde (MDA) levels were increased by ferric ammonium citrate (FAC) and decreased by deferoxamine (DFO) in PC12 cells after 48 hours of culture (flow cytometry).

(A) ROS level was significantly higher in FAC groups under high glucose concentration compared to HGG. ROS level was significantly decreased after adding DFO.

(B) MDA index was significantly increased in FAC groups under high glucose concentration compared to HGG. MDA index was significantly decreased after adding DFO.

Data are shown as mean ± SD from triplicate experiments. One-way analysis of variance was adopted for multiple-group comparison. Two-tailed Student's t-test was used for intergroup comparison. aP < 0.05, vs. HGG; bP < 0.05, vs. 25 μmol/L FAC group; cP < 0.05, vs. 100 μmol/L FAC group; dP < 0.05, vs. 400 μmol/L FAC group.

NGG: Normal glucose concentration group; HGG: high glucose concentration group; FAC25: 25 μmol/L FAC group; FAC100: 100 μmol/L FAC group; FAC400: 400 μmol/L FAC group; FAC + DFO: 400 μmol/L FAC + 200 μmol/L DFO group.