Figure 2.

Effects of persimmon leaf flavonoid on intercellular adhesion molecule-1 expression in the cerebral cortex and hippocampus at 24 hours after cerebral ischemia/reperfusion (immunohistochemical staining, × 400).

Except for the sham surgery group, rats from the other groups were used to establish models of cerebral ischemia/reperfusion injury. Rats from the preprocessing model group were subjected to ischemic preconditioning before ischemia/reperfusion. Rats from the high-, moderate-, and low-dose persimmon leaf flavonoid groups and ginaton group were administered 200, 100, 50 mg/kg persimmon leaf flavonoid or 20 mg/kg ginaton on the basis of brain ischemic tolerance, followed by modeling of ischemia/reperfusion. Compared with the ischemia/reperfusion group, intercellular adhesion molecule-1 expression in the cerebral cortex and hippocampus was decreased in rats treated with ginaton and persimmon leaf flavonoid. Moreover, the effect of high-dose persimmon leaf flavonoid and ginaton was obvious.