Figure 1.

Effect of flavonoids from Scutellaria baicalensis Georgi (SSF) on Morris water maze performance following cerebral ischemia/reperfusion in rats.

Rats were daily and orally administered SSF (35, 70 and 140 mg/kg) for 12 days, from days 2 to 13 after operation. Each rat was subjected to two trials daily for 5 consecutive days from day 8 after operation. Data are expressed as the mean ± SEM. ^aP < 0.01, vs. sham-surgery group; ^bP < 0.01, vs. model group.

(A) Mean latency to find the hidden platform in the learning ability acquisition trial. Data were analyzed by two-way analysis of variance (group × days, 5 × 5) with repeated measures (n = 8).

(B) Time spent in target quadrant within 60 seconds in the probe trial (no platform). Each rat was immediately subjected to 60-second observations following the last learning ability acquisition trial on day 13 after operation. Groups differences were analyzed by one-way analysis of variance followed by the Duncan's multiple-range test (n = 8).