Figure 4.

Morphology of injured spinal cord tissue after cell transplantation (hematoxylin-eosin staining, × 40).

(A) Spinal cord tissue fracturing, scar formation, structural disorder, and obvious cavity formation were visible in the simple PLGA group.

(B) In the BMSCs + Schwann cells + PLGA group, typical neuron-like morphological changes were observed, and the tissue cavity was smaller than in the simple PLGA group, but larger than in the Nogo-66 receptor gene-silenced cells + PLGA group.

(C) In the Nogo-66 receptor gene-silenced cells + PLGA group, typical neuron-like morphological changes were observed, and a cavity was not present.

BMSCs: Bone marrow mesenchymal stem cells; PLGA: Poly(D,L-lactide-co-glycolic acid).