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. 2013 Mar 15;8(8):677–685. doi: 10.3969/j.issn.1673-5374.2013.08.001

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Axonal regeneration in the injured spinal cord in rats 8 weeks after cell transplantation (transmission electron microscopy, × 8 000).

(A) In the simple PLGA group, glial scarring and a small amount of myelinated nerve fibers were visible (arrow).

(B) In the BMSCs + Schwann cells + PLGA group, there were many myelinated and unmyelinated nerve fibers (arrow).

(C) In the Nogo-66 receptor gene-silenced cells + PLGA group, a large number of myelinated and unmyelinated nerve fibers (arrow), axons, as well as intact regenerating axonal myelin were observed.

BMSCs: Bone marrow mesenchymal stem cells; PLGA: poly(D,L-lactide-co-glycolic acid).