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. 2014 Jun 1;9(11):1154–1162. doi: 10.4103/1673-5374.135318

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlation of MMP-9 with collagen IV and microvessel density in the brain of stroke-prone spontaneously hypertensive rats with cerebral infarction.

Linear correlation analysis showed that the number of MMP-9-positive cells and blood vessels positively correlated with microvessel density and the number of collagen IV-positive discontinuously-labeled blood vessels. The correlations were positive for MMP-9-positive cells versus microves-sel density (r = 0.754; A) and versus collagen IV-positive discontinuously-labeled blood vessels (r = 0.845; B); and for MMP-9-positive microvessels versus microvessel density (r = 0.767; C) and versus collagen IV-positive discontinuously-labeled blood vessels (r = 0.871; D). The correlations were negative for the number of collagen IV-positive continuously-labeled blood vessels versus MMP-9-positive cells (r = –0.672; E) and versus MMP-9-positive blood vessels (r = –0.719; F). MVD: Microvessel density; MMP-9: matrix metalloproteinase-9.