Figure 7.

Effect of scutellaria baicalensis stem-leaf total flavonoid (SSTF) on the blood-brain barrier ultrastructure in cerebral ischemia-reperfusion injured rats (transmission electron microscopy, scale bar: 2 μm).

(A) In the control group, capillary endothelial cells, the basement membrane and the glial cell pedal plate were continuous and intact. (B) In the sham group, the ultrastructure was similar to that in the control group. The structure was intact.

(C) In the model group, capillaries were closed, endothelial cytoplasm was condensed, the basement membrane and glial membrane were dissolved, and the pedal plate was reticulated. (D) In the SSTF low-dose group, the capillary endothelium was continuous, the basement membrane was not intact, and the glial pedal plate had begun to degenerate.

(E) In the SSTF medium-dose group, the capillary endothelium and the basement membrane were continuous and intact, and the glial pedal plate partially degenerated, and the blank areas were significantly reduced. (F) In the SSTF high-dose group, the capillary endothelium was close to normal, the basement membrane was uniform and smooth, and a small amount of the glial pedal plate was lost. However, vesicles, filaments and mitochondria were still visible.