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. 2014 Feb 15;9(4):413–419. doi: 10.4103/1673-5374.128248

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Peripheral neuropathy in ^K141NHSPB8 transgenic (Tg) mice.

(A) At around 6 months of age, ^K141NHSPB8 Tg mice developed an unsteady gait and signs of muscle weakness of the hind limbs. The left is a Nontg mouse and the right is a Tg mouse. (B) ^K141NHSPB8 Tg mice showed a slightly outward positioning of the hind paws in footprint analysis, with the pattern of the Nontg animals (upper panel) slightly different from that of Tg animals (lower panel). (C) Analysis of the footprint patterns of the Nontg (n= 9) and Tg (n= 9) mice. The mean hind paw angle ± SEM is shown (P < 0.05, two sample t-test). HSPB8: Heat shock protein B8; Nontg: wild type.