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. 2014 Mar 15;9(6):646–652. doi: 10.4103/1673-5374.130112

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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RU-486 blocked serotonin-elicited serotonin transporter (SERT) activity.

(A) Serotonin (50 μmol/L) response in SERT-expressing oocytes, when co-applied with varied glucocorticoid receptor antagonist, mifepristone (RU-486) concentrations. Sweeps 1–6: 3.16, 10, 31.6, 100, 316, and 1,000 μmol/L serotonin. (B) SERT currents were recorded in response to sero-tonin (50 μmol/L). After the serotonin response reached a steady-state plateau, addition of RU-486 (1–100 μmol/L) produced concentration-de-pendent outward currents of SERT. Each experiment was repeated six times. Sweeps 1–6: 3.16, 10, 31.6, 100, 316, and 1,000 μmol/L serotonin + 100 μmol/L RU-486.