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. 2014 Apr 1;9(7):741–748. doi: 10.4103/1673-5374.131580

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Houshiheisan on NeuN expression in the ischemic penumbra of rat brain cortex 72 hours after cerebral ischemia (immunofluorescence staining, × 400; scale bars: 50 μm).

Wind-dispelling drugs, deficiency-nourishing drugs, and Houshiheisan increased cortical NeuN expression after cerebral ischemia. (A) Sham sur-gery group; (B) model group; (C) wind-dispelling drug group; (D) deficiency-nourishing drug group; (E) Houshiheisan group. The number of NeuN-positive neurons was significantly higher in the ischemic penumbra in the Houshiheisan, wind-dispelling drug and deficiency-nourishing drug groups compared with the model group. Arrows indicate NeuN-positive cells. NeuN: Neuronal nuclear antigen.