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. 2014 Jun 15;9(12):1241–1248. doi: 10.4103/1673-5374.135333

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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NF-200 immunohistochemistry in the injured rat spinal cord following miR-124-transfected bone marrow-derived mesenchymal stem cell (BMSC) transplantation.

(A–C) NF-200-immunoreactive cells in the control, miR-124^– and miR-124⁺ groups. Scale bars: 250 μm. High magnification images of the insets in (A–C), scale bars: 25 μm. (D) Compared to the control and miR-124^– groups, the percentage of NF-200-positive cells was significantly higher in the miR- 124+ group on day 7 after spinal cord injury (*P < 0.05; Student's t-test). Bars represent mean ± SD (n = 3). (E) Overexpression of miR-124 in BMSCs promoted functional recovery following spinal cord injury. Hind limb recovery was assessed from day 1 to day 42 after spinal cord injury using the Basso, Beattie and Bresnahan (BBB) score. *P < 0.05, vs. the other two groups (Student's t-test). Bars represent mean ± SD (n = 10).