Table 3A.
Changes in the percentage (%) of the lymphocyte population by irradiation.
| Authors of referenced studies | Lymphocytes | Non-irradiated MRL-lpr/lpr group versus normal group | Irradiated MRL-lpr/lpr group versus non-irradiated MRL-lpr/lpr group | Status after irradiation | Sampling date |
|---|---|---|---|---|---|
| Tanaka et al. 2005 | CD3+CD4+ | ↓ | ↑ | Reduced level was increased | Splenocytes were obtained 3 weeks after last irradiation. |
| CD3+CD8+ | ↓ | ↓ | Reduced level was further slightly decreased | ||
| CD3+CD4– CD8–B220+ |
↑ | ↓ | Markedly increased level was decreased | ||
| Pan NK+ (NK cell) | ↘ | ↑ | Slightly reduced level was increased | ||
| Tago et al. 2008 | CD3+CD4–
CD8–B220+ |
↑ | ↓ | Increased level was decreased at 20 weeks old | Population of splenocyte subsets was obtained in 12- to 18-week-old mice |
| CD4+ | Not examined | ↑ | Significantly increased | ||
| CD19+ | Not examined | ↓ | Significantly decreased | ||
| CD8+ | Not examined | → | Not changed | ||
| Ootsuyama et al. 2003 | CD4–CD8 | ↑ (Non-irradiated MRL/gld group versus normal group) | ↓ (Irradiated MRL/gld group versus non-irradiated MRL/gld group) | Markedly increased level was decreased by irradiation (0.2Gy or 0.5Gy, 5 times/week for 4 weeks) | Splenocytes were obtained 3 days after last irradiation. |
↑ : significantly increased
↓ : significantly decreased
→ : not significantly different (same level)
↗ : not significant but increasing tendency
↗ : not significant but decreasing tendency.