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Cardiac neuronal nitric oxide synthase (nNOS) during disease progression
nNOS is functionally expressed in healthy myocardium. From the early stages of disease progression (pre-disease) to hypertension, cardiac nNOS is upregulated and facilitates myocyte relaxation. The mechanisms mediating nNOS shift from PKA-dependent PLN-Ser16 to PKG-dependent PLN-Ser16 at pre-disease and PKG-dependent cMBP-C Ser273 and cTnI Ser23/24 at hypertension. Myocyte contraction is not affected by nNOS.
