Table I.
The combination of AKT inhibition and autophagy blockade synergistically reduces cell viability of metastatic ovarian cancer cells
| Sample | Spautin-1 + Akti-1/2 | Sample | Chloroquine + Akti-1/2 | ||
|---|---|---|---|---|---|
| CI value | Description | CI value | Description | ||
| iOvCa147-E2 | 0.63 | Synergy | iOvCa147-E2 | 1.04 | Additive |
| EOC154 | 0.50 | Synergy | EOC148 | 1.05 | Additive |
| EOC148 | 0.41 | Synergy | EOC154 | 0.84 | Slight synergy |
| EOC129 | 0.27 | Synergy | EOC129 | 0.72 | Moderate synergy |
| EOC122 | 0.23 | Strong synergy | EOC81 | 0.59 | Synergy |
| EOC105 | 0.22 | Strong synergy | EOC118 | 0.56 | Synergy |
| EOC81 | 0.16 | Strong synergy | EOC105 | 0.39 | Synergy |
| EOC118 | 0.11 | Strong synergy | EOC122 | 0.36 | Synergy |