Table II.

P values and odds ratios of SNPs associated with CRC in European-ancestry populations or of SNPs in LD with those variants^a

					Replicationb										GWASc
					AA					EA					Freq	OR
Gene	Reference SNP (rs)d	SNP (rs) in LD	Position	All	Case Freq	Cont Freq	Best OR	Min P	Best Mod	Case Freq	Cont Freq	Best OR	Min P	Best Mod
BMP4	4444235		54410919	C	0.31	0.34	0.87	0.892	Dom	0.43	0.43	1.10	0.287	Dom	0.46	1.11
	1957636		54560018	A	0.74	0.75	1.00	0.478	Rec	—	—	—	—	—	0.40	1.08
		1957606	54526105	A	0.75	0.75	1.00	0.422	Rec	—	—	—	—	—
GREM1	10318		33025979	A	0.05	0.03	60.05	0.011*	Rec	0.13	0.14	1.34	0.291	Rec	0.18	1.18
	4779584		32994756	C	0.69	0.68	1.12	0.040	Rec	0.48	0.51	0.86	0.855	Rec	0.18	1.19
		12902616	32997175	G	0.82	0.78	1.28	0.005*	Rec	0.59	0.61	0.82	0.791	Rec
	11632715		33004247	A	0.30	0.29	2.36	0.004*	Rec	0.32	0.33	0.99	0.506	Rec	0.47	1.12
		76211684	33002938	T	0.31	0.29	2.63	0.002*	Rec	0.32	0.33	1.00	0.505	Rec
CDH1	9929218		68820946	A	0.32	0.30	0.97	0.429	Rec	0.29	0.33	0.68	0.065	Rec	0.29	0.88
		8044058	68807088	A	0.23	0.23	1.34	0.138	Rec	0.24	0.29	0.54	0.015	Rec
	1862748		68832943	T	0.17	0.20	0.82	0.023*	Add	0.82	0.29	0.81	0.036	Add	0.31	0.88
		4783685	68834107	T	0.08	0.10	0.72	0.018*	Dom	0.26	0.32	0.74	0.005	Add
SMAD7	4939827		46453463	C	0.36	0.35	1.09	0.561	Dom	0.50	0.52	0.80	0.090	Add	0.49	0.85
	12953717		46453929	T	0.33	0.31	1.26	0.103	Rec	0.42	0.44	0.97	0.562	Rec	0.42	1.19
RHPN2	10411210		33532300	T	0.42	0.42	0.86	0.153	Dom	0.09	0.13	0.74	0.036	Add	0.10	0.79
		12459751	33538783	G	0.79	0.78	0.86	0.102	Dom	0.93	0.89	0.66	0.021	Add
	7259371		33534641	A	0.69	0.68	1.03	0.596	Rec	0.21	0.24	0.88	0.208	Rec	0.18	0.86
		2042190	33532716	C	0.73	0.74	1.00	0.512	Add	0.19	0.23	0.55	0.054	Rec	0.18	0.86

^aSNP analytic data were included in this table if (1) the SNP was a reference SNP identified in European-ancestry GWAS for colorectal cancer or (2) the SNP was in linkage disequilibrium (r ² > 0.8) with a reference SNP and obtained a smaller P value in the analysis. Add, additive genetic model; All, allele; Cont, control; Dom, dominant genetic model; freq, frequency; Rec, recessive genetic model.

^bReference SNPs are listed in Table I. The GREM1 SNP rs16969681 was not included in Table II because the imputation quality score was < 0.5.Three genetic models were tested. The best model (mod) and best OR are the ones associated with the smallest P value (min p).

^cThese data are from the reported GWAS studies in individuals of European descent (see Table I).

^dReference SNPs are listed in Table I. The GREM1 SNP rs16969681 was not included in the Table because the imputation quality score was < 0.5.

^*Statistically significant P value (in bold) at the 0.05 level after controlling for multiple testing.