Table III.
trans-eQTL analysis for significant associations between the GWAS SNPs and all the genes
| Locus | SNP | Gene symbol | Gene name | r* | P value | Bonferroni$ |
|---|---|---|---|---|---|---|
| 11q23.1 | rs3802842 | GNG13 | Guanine nucleotide binding protein (G protein). Gamma 13 | −0.44 | 5.4E-9 | Y |
| 11q23.1 | rs3802842 | BMX | BMX non-receptor tyrosine kinase | −0.39 | 6.0E-7 | N |
| 11q23.1 | rs3802842 | HTR3E | 5-hydroxytryptamine (serotonin) receptor 3E. Ionotropic | −0.37 | 1.9E-6 | N |
| 11q23.1 | rs3802842 | SH2D6 | SH2 domain containing 6 | −0.37 | 2.1E-6 | N |
| 11q23.1 | rs3802842 | PSTPIP2 | Proline-serine-threonine phosphatase interacting protein 2 | −0.36 | 3.4E-6 | N |
| 11q23.1 | rs3802842 | LRMP | Lymphoid-restricted membrane protein | −0.35 | 1.2E-5 | N |
| 11q23.1 | rs3802842 | AZGP1 | Alpha-2-glycoprotein 1. Zinc-binding | −0.33 | 3.2E-5 | N |
| 12q13.12 | rs11169552 | HAL | Histidine ammonia-lyase | −0.41 | 9.2E-8 | Y |
| 12q13.12 | rs11169552 | TERF2 | Telomeric repeat binding factor 2 | 0.37 | 3.0E-6 | N |
| 12q13.12 | rs11169552 | HSP90AB1 | Heat shock protein 90kDa alpha (cytosolic). Class B member 1 | 0.36 | 4.3E-6 | N |
| 12q13.12 | rs11169552 | SIAH2 | Siah E3 ubiquitin protein ligase 2 | 0.36 | 5.0E-6 | N |
| 12q13.12 | rs11169552 | BCL7A | B-cell CLL/lymphoma 7A | 0.36 | 5.7E-6 | N |
| 12q13.12 | rs11169552 | MED28 | Mediator complex subunit 28 | 0.35 | 1.0E-5 | N |
| 12q13.12 | rs11169552 | AHSA1 | AHA1. Activator of heat shock 90kDa protein ATPase homolog 1 (yeast) | 0.34 | 2.3E-5 | N |
| 12q13.12 | rs11169552 | CCDC71 | Coiled-coil domain containing 71 | 0.33 | 3.1E-5 | N |
| 12q13.12 | rs11169552 | POM121 | POM121 transmembrane nucleoporin | 0.33 | 3.7E-5 | N |
*Pearson partial correlation coefficient.
$Significant after Bonferroni correction (P value < 1e-7).