Table II.
Meta-analysis association results between the top 14 SNPs (P < 0.05) and endometrial cancer
| SNP | Region | Position (bp) | Locus | Risk Allelea | Other Allele | Number of studiesb | OR per allelec (95% CI) | P value | P heterogeneity | Initial GWAS (reference) |
|---|---|---|---|---|---|---|---|---|---|---|
| rs10936599 | 3q26.2 | 169492101 | MYNN | C | T | 7 | 1.10 (1.00, 1.20) | 0.042 | 0.52 | Colorectal cancer (34) |
| rs7679673 | 4q24 | 106061534 | TET2 | C | A | 8 | 0.87 (0.81, 0.93) | 7.37×10−5 | 0.66 | Prostate cancer (30) |
| rs889312 | 5q11.2 | 56031884 | MAP3K1 | C | A | 9 | 0.93 (0.87, 1.00) | 0.048 | 0.02 | Breast cancer (35) |
| rs4624820 | 5q31.3 | 141681788 | SPRY4 | G | A | 8 | 1.06 (1.00, 1.14) | 0.049 | 0.12 | Testicular cancer (36) |
| rs763780 | 6p12.2 | 52101739 | IL17F | G | A | 6 | 0.76 (0.62, 0.94) | 0.012 | 0.73 | Pancreatic cancer (37) |
| rs9502893 | 6p25.3 | 1340189 | FOXQ1 | G | A | 7 | 1.10 (1.01, 1.19) | 0.023 | 0.32 | Pancreatic cancer (38) |
| rs2981582 | 10q26.13 | 123352317 | FGFR2 | A | G | 8 | 0.90 (0.84, 0.97) | 0.005 | 0.07 | Breast cancer (35) |
| rs1219648 | 10q26.13 | 123346190 | FGFR2 | G | A | 8 | 0.92 (0.87, 0.99) | 0.024 | 0.02 | Breast cancer (39) |
| rs2981579 | 10q26.13 | 123337335 | FGFR2 | T | C | 8 | 0.93 (0.87, 0.99) | 0.032 | 0.02 | Breast cancer (40) |
| rs7127900 | 11p15.5 | 2233574 | IGF2, IGF2AS, INS, TH | A | G | 8 | 0.91 (0.84, 0.98) | 0.021 | 0.60 | Prostate cancer (30) |
| rs9600079 | 13q22.1 | 73728139 | None | T | G | 7 | 0.91 (0.84, 0.99) | 0.027 | 0.08 | Prostate cancer (41) |
| rs1978503 | 18q21.2 | 53664282 | None | A | G | 9 | 0.88 (0.81, 0.95) | 0.002 | 0.55 | Breast cancer (42) |
| rs16951095 | 18p11.31 | 7042911 | LAMA1 | C | T | 6 | 0.78 (0.94, 0.66) | 0.011 | 0.08 | Lung cancer (43) |
| rs738722 | 22q12.1 | 29130012 | CHEK2 | T | C | 7 | 1.10 (1.01, 1.20) | 0.037 | 0.71 | Esophageal cancer (44) |
CI, confidence interval; OR, odds ratio.
aAllele associated with increased risk as indicated in the first published GWAS paper.
bNumber of studies with association result.
cAdjusted for age, body mass index, top principal components for each study and calculated using fixed effects model.