Table III.
Logistic regression analysis of the association between HERV-K gag mRNA levels and prostate cancer by smoking status
| Univariate analysis | Multivariable analysisa | |||||
|---|---|---|---|---|---|---|
| OR (95% confidence interval) | P value | N | OR (95% confidence interval) | P value | n | |
| Never smokers | ||||||
| Gag mRNA (continuous) | 1.41 (1.21–1.63) | <0.0001 | 121 | 1.43 (1.22–1.67) | <0.0001 | 121 |
| Gag mRNAb (median) | 8.07 (3.03–21.5) | <0.0001 | 121 | 9.38 (3.33–26.4) | <0.0001 | 121 |
| Former smokers | ||||||
| Gag mRNA (continuous) | 1.44 (1.27–1.63) | <0.0001 | 173 | 1.48 (1.29–1.69) | <0.0001 | 173 |
| Gag mRNA (median) | 13.8 (6.27–30.4) | <0.0001 | 173 | 17.4 (7.29–41.8) | <0.0001 | 173 |
| Current smokers | ||||||
| Gag mRNA (continuous) | 1.93 (1.31–2.87) | 0.001 | 64 | 2.35 (1.33–4.16) | 0.003 | 64 |
| Gag mRNA (median) | 25.5 (4.56–142) | 0.001 | 64 | 30.2 (4.40–208) | 0.001 | 64 |
aAdjusted for age at diagnosis and race/ethnicity.
bHERV-K gag levels were dichotomized using the median expression in the control population.