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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Mol Cancer Ther. 2014 Feb 21;13(5):1044–1053. doi: 10.1158/1535-7163.MCT-13-0550

Figure 4. The combination AEB071/BYL719 induces apoptosis in GNAQ mutant cells.

Figure 4

A. Cells were treated with AEB071/BYL719 for 72 hrs and labeled with MPM-2, stained with propidium iodide, and analyzed by flow cytometry. SubG1 fractions were quantified using Flow jo. Results represent the mean of three independent experiments. B. Uveal melanoma cell lines were treated with drug for 24 hr. Western Blots were performed for cleaved PARP (Poly (ADP-ribose) polymerase). α-Tubulin was used as a loading control.