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Sevoflurane anesthesia in infancy - Minimum alveolar concentration (MAC) survival and arterial blood gas analyses.
Inspired MAC of sevoflurane, as determined by tail clamping, of P7 rats (n=30) during two separate 4 hour anesthetic exposures (A). Survival of P7 rats over four hours of sevoflurane at 1 MAC during three separate anesthetic exposures (B). Sevoflurane depressed respiration and caused hypercarbia (C) but not hypoxemia (D).
