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. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: Cell. 2013 Jun 20;153(7):1552–1566. doi: 10.1016/j.cell.2013.05.041

Figure 4. Genetic depletion of Myc expression abolishes leukemia-initiating activity in T-ALL.

Figure 4

Myc+/+Mx1Cre+ or Myc+/+Mx1Cre+ bone marrow was transduced with Notch1ΔE and transplanted into lethally-irradiated recipients. Notch1ΔE+ T-ALL cells were measured in peripheral blood 2 weeks post-transplant (a) (top panel) and 7 days following pI:pC treatment (bottom panel). (b) FACS analysis showing frequency of Notch1ΔE+ cells expressing CD4/CD8 (top panels) and CD4−CD8−CD25hiIL-7Rα+ (bottom panels) immunophenotype within spleen following Cre induction. (c) Frequency of Notch1ΔE+ PBMC in secondary recipients of Myc wild type and deficient T-ALL cells 2 weeks post transplant.