Table 3.

Comparison of HPV test positivity by Trovagene urine HPV test and urine testing by Linear Array HPV test (LA-HPV) stratified by categories of positive signal strength thresholds of cervical HPV detection by LA-HPV.

Type of sample positivity	No. of positive urine HPV test samples / no. of positive cervical samples (%) by signal strength of LA-HPV			No. of positive urine HPV test samples / no. of positive cervical samples (%) by signal strength o f LA-HPV
	Strong signal	≤Moderate signal	P value	≥Moderate signal	≤Weak signal	P value
Trovagene urine HPV test positive	45/48 (93.8)	6/7(85.7)	0.43	48/51 (94.1)	3/4 (75.0)	0.27
Urine LA-HPV test positive	41/48 (85.4)	4/7 (57.1)	0.09	43/51 (84.3)	2/4 (50.0)	0.01

Footnote: Hybridization signal strengths of the cervical samples presented in the Table is noted on a semi-quantitative scale as strong, moderate, weak, very weak and extremely weak signals. “≥Moderate signal” refers to strong or moderate signals, “≤moderate signal” refers to moderate, weak, very weak, or extremely weak signals, “≤weak signal” refers to weak, very weak, or extremely weak signals. The p-values for comparing differences in proportions of urine HPV positivity by corresponding categories of cervical signal strength positivity were computed by the Fisher's exact test.