Figure 6. Effect of deletion of HCN and CaCC channels and activation of CaKC: scenario 2.

A) Steady state time evolution of time series calculated as described in Fig 2. Average oscillations for the wild type are in black while oscillations under deletion of the CaCC- HCN as well as CaKC activation nodes are in red. Notice for the treated network, a 3-step module is indicated in the figure. B) Fourier spectra calculated from 1000 steady-state steps of the time series shown in A). Period 4 and 8 Fourier modes and their harmonics are shown in black. For the NFA-treated network the spectrum shown in red, determined from 1000 points of the steady-state [Ca²⁺] time series, presents a period-3 Fourier mode. C) A four element running average of the series corresponding to (A), manifests an underlying repeated 8 module for the wild type while the NFA-treated network preserves its period 3 oscillation. D) Result of performing a running average as in (C) using an 8 element window instead. Here the wild type oscillations are wiped out (black graph) while the 3 module envelop (in red) is evidenced for the triply blocked NFA treated case. E) Running average of size 3 produces the complete flattening of the NFA-treated network while period 8 persists in the WT.