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. 2012 Jul 5;21(17):3081–3090. doi: 10.1089/scd.2012.0277

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Copyright 2012, Mary Ann Liebert, Inc.

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FIG. 3. — SB431542 treatment down-regulates, while TGFβ further up-regulates the expression of genes that are up-regulated in 3D structures versus monolayers. (A) Significantly modulated (P<0.05) gene expression levels in CSps/IICSps obtained in presence of TGFβ (n=7) versus untreated controls (n=13) assessed by Q-RT-PCR and presented on a logarithmic scale. (B) Significantly modulated (P<0.05) gene expression levels in EDCs/CDCs plated to form CSps/IICSps, respectively, in the presence of SB431542 10 μM for 7 days (n=6) versus untreated CSps/IICSps as control (n=13). (C) Normalized gene expression levels that were significantly modulated both in TGFβ (n=7) and SB431542 (n=6) treated samples versus untreated CSps (n=13). SB, SB431542; SB/TGF, SB431542 treated CSps versus TGFβ treated CSps, both normalized versus untreated CSps.