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. 2014 Aug 27;9(8):e105886. doi: 10.1371/journal.pone.0105886

Figure 5. Amplification of Cdk6 and Cdk14 in propagated CB42 tumors.

Figure 5

A). aCGH profile of CB42 primary tumor and passage 3 propagated tumor. A 3.5 Mb amplicon on chromosome 5 was detected only in the propagated tumor. Probes for Cdk6 were colored in yellow and probes for Cdk14 were colored in blue. B). RT-PCR analysis for the expression of 7 genes in the chromosome 5 amplicon. The relative expression values of CB42P4 tumors (n = 4) were normalized to those of normal cecal epithelium (n = 4). C). Western Blot analysis for levels of Cdk4 and Cdk6 in CB42 and 4 human colon cancer cell lines. D). Frequency of CDK6 and CDK14 amplification in human cancer samples from 13 tissue types. Data were retrieved from CBio website.