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(A) Rat organ weights (lung, liver, kidney, and spleen) after HDAS-PEG2K-LEH and saline administration for 4 weeks (0, 7, 14, 21 days) at a dose rate of 10 ml/kg. The values are mean ± SEM. (B) Histology of lung, liver, spleen, and kidney. One group received repeated weekly injections of HDAS-PEG2K-LEH for 4 weeks (10 ml/Kg), whereas the other group was given equal volume of saline (control).
